Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics
نویسندگان
چکیده
منابع مشابه
Disease-related mutations among Caribbean Hispanics with familial dementia
Pathogenic mutations in the three known genes - the amyloid precursor protein (APP), presenilin 1 (PSEN1), presenilin 2 (PSEN2) - are known to cause familial Alzheimer's disease (AD) and tend to be associated with early-onset AD. However, the frequency and risk associated with these mutations vary widely. In addition, mutations in the frontotemporal lobar degeneration (FTLD) genes - the microtu...
متن کاملFamilial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.
OBJECTIVES To reexamine the association between the apolipoprotein E epsilon4 allele (APOE epsilon4) and familial Alzheimer disease (AD), and to search for novel genes that may be associated with susceptibility in Caribbean Hispanic families with a history of AD. METHODS Families were identified in Caribbean Hispanic communities in the greater New York City area, the Dominican Republic, and P...
متن کاملExpanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease.
OBJECTIVES To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions. DESIGN Family-based linkage analysis. SETTING Probands with familial LOAD identified in clinics in the Dominican Republic, Puerto Rico, and the United States. Patients We conducted a genome scan in 1161 members primarily clinically diagn...
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15 صفحه اولsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2004
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001538